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This question has gained traction as social media influencers tout berberine as "nature's Ozempic," prompting patients and clinicians to examine whether this botanical supplement truly mimics prescription incretin therapies

The National Institute for Health and Care Excellence (NICE) has not issued guidance on GLP-1 receptor agonists for addiction treatment, and these medications should not be considered established therapies for substance use disorders

In rare cases, the change in central nervous system receptor activation can unmask or exacerbate anxiety or depression that the previous medication was inadvertently managing

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