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Additionally, this would place intracranial pressure control as one of the mechanisms underlying migraine, a pharmacologically-targetable one. Braca added that they plan to conduct a double-blind randomized placebo-controlled study as this was a pilot, exploratory study

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Those who switched to placebo regained approximately 14% of their body weight over 52 weeks

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doi: 10.1038/s41591-022-02026-4