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Some patients report feeling tired or low-energy during the first week or two of treatment

Front Pharmacol 12:648636 Ma J et al (2025) Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis

For 6 mm needles, patients may need to pinch the skin gently to lift subcutaneous tissue away from muscle, then inject at a 90-degree angle

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Bottom line Pregnancy brings many changes to women's bodies, and it can be upsetting to lose your pre-pregnancy body

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