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Transitioning between these medications may require a washout period or dosage adjustments to minimize the risk of side effects and ensure safe use

2017;15(5):631-649.e10

Miyawaki K, Yamada Y, Ban N, et al

On the other hand, some people are particularly sensitive to GI medications or have a history of gastroparesis or other digestive conditions

ICH E9 (R1) addendum on estimands and sensitivity analysis in clinical trials to the guideline on statistical principles for clinical trials

For all HRQoL measures, participants with physical function limitations at baseline showed greater improvements than those without limitations