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Description
The beneficial actions based on activation of the entero-insular axis are complex and multitargeted, involving the gut, brain, pancreas, and liver

This is why cagrilintide, which operates through completely different receptors, makes a more logical combination partner than additional GLP-1 agonists

For people with chronic obesity and cardiovascular complications, GLP-1 receptor agonists are preferred to amphetamine-based therapies like phentermine, which can worsen blood pressure, heart rate, anxiety, and insomnia

Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta-analysis

Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 expression

Nature Medicine 212736
