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The beneficial actions based on activation of the entero-insular axis are complex and multitargeted, involving the gut, brain, pancreas, and liver

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This is why cagrilintide, which operates through completely different receptors, makes a more logical combination partner than additional GLP-1 agonists

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For people with chronic obesity and cardiovascular complications, GLP-1 receptor agonists are preferred to amphetamine-based therapies like phentermine, which can worsen blood pressure, heart rate, anxiety, and insomnia

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Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta-analysis

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Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 expression

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Nature Medicine 212736

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