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An example of how knowledge of the two-domain model can be used to design and synthesize novel ligands has recently been described in an elegant study by Devigny et al

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Handgraaf S, Dusaulcy R, Visentin F, et al

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GLP-1 RAs promote weight loss [41], hence our findings of an increase in weight with GLP-1 RA therapy at 5 years was interesting

This imbalance could lead to potential misestimation of GLP-1 RA effects when generalized to all KTRs with T2DM