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Summary: Current evidence does not support a causal link between Mounjaro (tirzepatide) and suicidal thoughts, according to UK and European regulatory reviews

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Those starting with higher body fat should expect initial fat loss with muscle preservation, transitioning to muscle gain as body composition improves

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Moreover, due to the observational nature of pharmacovigilance data, no causal relationship between exposure and suspected ADRs can be established, and the findings should be interpreted as reporting associations rather than evidence of causality