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Approximately 90% of GLP-1 is metabolized by DPP-4 before reaching the central venous circulation ( 2 after a meal in healthy subjects is usually less than 10 pmol/L due to the rapid degradation of DPP-4 ( In order to solve the problem of rapid inactivation of GLP-1 by DPP-4 degradation, GLP-1RAs and DPP-4 inhibitors have been developed to treat T2DM (Kim and Jang, 2015

1 About Wegovy (semaglutide 2.4 mg) Wegovy (once-weekly subcutaneous semaglutide 2.4 mg) is a GLP-1 receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adults with a BMI of 30 kg/m 2 or greater (obesity), adults with a BMI of 27 kg/m 2 or greater (overweight) in the presence of at least one weight-related comorbid condition, and paediatric patients aged 12 years and older with an initial BMI at the 95th percentile or greater for age and gender (obesity) 8

Evidence supports metformins antiviral properties, with studies linking its use to reduced herpesvirus replication and a lower risk of herpes zoster and postherpetic neuralgia in DM2 patients, particularly at higher cumulative doses 49,50,51

doi: 10.2337/dc16-0917 47 PfefferMAClaggettBDiazRDicksteinKGersteinHCKberLVet al

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