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In addition, some aspects of GLP-1 beyond weight loss, such as preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, still deserve a greater insight, especially in light of a possible therapeutic use in PCOS women independently of obesity

Future research should prioritize human trials, bioavailability optimization, and synergistic formulations to harness the full therapeutic potential of plant-derived GLP-1 agonists in metabolic disorders.

Background: The evidence on berberine stimulating the secretion of GLP-1 in intestinal L cell has been studied

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Plasma concentrations of semaglutide were determined using a validated liquid chromatography-tandem mass spectrometry (LCMS/MS) method

For users this could segway into an expansion of the private market and for payers this could provide an affordable entry point for public reimbursement