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Hunger increases, fullness becomes less reliable, and metabolic adaptation makes maintenance difficult

The discomfort from an intramuscular injection tends to be deeper and more aching compared to the mild sting of a subcutaneous injection

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In STEP 1 and SURMOUNT-1, semaglutide and tirzepatide produced large, durable reductions in body weight, setting a new efficacy benchmark for pharmacotherapy [1,2]

Naunyn-Schmiedebergs Arch

Exenatide is also resistant to degradation by DPP-4 because it has Gly8 in the place of Ala8, the residue on which DPP-4 acts
