no more compounding glp 1 drugs GLP-1 Compounding: When Innovation May Mean Liability Newly released International Foundation survey

doi: 10.1111/anae.14180

Are tirzepatide and retatrutide structurally similar?# Yes, both are 39-amino-acid peptides with a C20 fatty diacid conjugated to a lysine residue that enables albumin binding and extends circulating half-life

2023;72:81-LB

Another literature review, Pharmacological Profile of Once-Weekly Injectable Semaglutide for Chronic Weight Management, also concluded that semaglutide 2.4 mg was more efficacious than other approved weight-management medications, which include once-daily liraglutide 3.0 mg, orlistat (three times daily oral administration), phentermine-topiramate (once-daily oral administration) and naltrexone-bupropion (twice-daily oral administration)

Among GLP1 RA initiators, these percentages were 73% (HbA1c), 36% (eGFR), 31% (LDL cholesterol), and 62% (triglycerides)

2023 Jun 15;14:1172400