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Air injected subcutaneously is simply absorbed by surrounding tissues without entering the circulatory system, making it clinically insignificant

However, the endogenous secretion of GLP-1 in mice is insufficient to significantly increase the number of glutamatergic neurons in this region, potentially exacerbating anxiety-like behaviors

Furthermore, it has long been theorized that cancer cells exhibit heightened glucose uptake and rely on glucose as a primary fuel for proliferation because it is a substrate cancer cells use as an energy source in aerobic glycolysis, resulting in tumor progression [27]

It is worth emphasizing that the gradual approach used did not reduce weight loss or compromise glycemic efficacy, reinforcing that tolerability, not symptom intensity, should guide dose advancement (22)

Diabetologia 53(11):22762279

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