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Protein intake in adults should not fall below 0.40.5 g/kg/day, as this can lead to muscle atrophy and functional impairments, while prolonged intake above 2 g/kg/day should be avoided due to potential adverse health effects [157]

Nature 510:8491 Xu W, Zhang D, Ma Y et al (2024) Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCepsilon-insulin receptor(T1150) phosphorylation pathway

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Initially developed to treat type 2 diabetes, Semaglutide was soon found to have powerful weight loss effects

installation of long-term healthful habits

Contact your GP or prescribing clinician if you experience : Severe or persistent vomiting or diarrhoea lasting more than 2448 hours, which may lead to dehydration, electrolyte imbalance, and potentially acute kidney injury Signs of dehydration , including dizziness, reduced urine output, dark urine, dry mouth, or feeling faint Severe abdominal pain , particularly if constant, worsening, or accompanied by fever, as this may indicate pancreatitisa rare but serious adverse effect of GLP-1 receptor agonists [19] [12] Pain in the upper right abdomen, fever, or yellowing of the skin/eyes (jaundice) , which could indicate gallbladder diseasea potential risk with GLP-1based therapies and weight loss [20] [12] Difficulty swallowing or chest pain after taking psyllium husk, which could suggest oesophageal obstruction Blood in stools or black, tarry stools , which require urgent investigation Unexplained weight loss beyond what is expected, or inability to maintain adequate nutrition Worsening glycaemic control or hypoglycaemia (low blood sugar), especially if taking Mounjaro alongside insulin or sulfonylureas Before starting psyllium husk or any new supplement whilst on Mounjaro, inform your healthcare provider