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The visual impact is dramatic for both, though the absolute number differs

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Reduced glucose metabolism in AD may be a consequence of reduced postsynaptic neurotransmission, since depolarizing agents trigger glucose uptake in the brain and the effect is reduced in AD (60)

In the STEP 3 trial of semaglutide combined with intensive lifestyle intervention (30 counseling visits across 68 weeks, including nutrition, physical activity, and other behavioral strategies, plus 8 initial weeks of meal replacements with liquid shakes, meal bars, or portion-controlled meals), individuals experienced a 16% reduction from baseline in body weight (versus 5.7% with intensive lifestyle intervention alone)