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The only shelf life that should be followed is the one stated on the IMP label or clinical trial protocol provided by the trial sponsor

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The placebo group lost 2.1%

Research indicates that although semaglutide did not significantly improve hepatic fibrosis, it had positive effects on hepatic steatosis, weight control, and diabetes-related parameters, offering a new therapeutic direction for patients with NASH and compensated cirrhosis ( A study showed that the long-term use of GLP-1RAs could reduce the risk of major adverse liver events (MALE) in patients with type 2 diabetes

This increases the risk of aspiration (inhalation of stomach contents into the lungs) during general anaesthesia when protective airway reflexes are suppressed

More time, more pressure, more bacterial migration