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data, which are subject to much less variability, whereas covariates on oral absorption rate and bioavailability were informed by data obtained following oral administration

The effects of GLP-1R activation are mediated by the activation of downstream signals that increase cellular cyclic AMP (cAMP) levels [33,34,35]

Age, insulin resistance status, baseline metabolism, and prior medication history also shape the 1mg response curve
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doi: 10.1038/ng.2606 [DOI] [PMC free article] [PubMed] [Google Scholar] 65
