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We will continue to scrutinise the data to see whether abnormal blood test results such as having pre-diabetes might predict a better response to exenatide, and whether there were more of these people in the earlier, smaller trials in which we found positive overall effects. The trial was supported by the UCL Comprehensive Clinical Trials Unit (UCL CCTU), the National Institute for Health and Care Research (NIHR), UCLH Biomedical Research Centre and the NIHR UCLH Clinical Research Facility

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The observed effects in maximal respiration and reserve capacity most likely occur due to increased glycolysis and consequent augmented flux of pyruvate into the Krebs cycle