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(2) excluding irrelevant works (e.g., conference papers, reviews, case reports, etc.)

Schematics indicating the GLP-1R aa sequences in each genotype ( Figures 2B, 2F, 2I ) are illustrated similar to the depiction by Doyle and Egan [32]

4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 Exenatide and lixisenatide are analogues of exendin4 (a peptide agonist of the GLP1 receptor, obtained from the Gila monster) 13

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Glycaemic efficacy Compared with placebo, reductions in HbA 1c levels ranged between 17.71 mmol/mol (1.62%) with tirzepatide 5 mg and 22.35 mmol/mol (2.06%) with tirzepatide 15 mg (Fig