sertraline and glp 1 GLP-1 receptor agonists GLP-1 and Antidepressants: Safety Guide
Description
NASH triggers cardiometabolic HFpEF in aging mice

doi:10.3390/diseases12090204 24

They do not replace GLP-1 therapy
Agonists that preferentially engage G protein signaling while avoiding -arrestin recruitment (such as exendin-phe1) produce stronger, longer-lasting insulin release

Common Side Effects The most common side effects are nausea, bloating, vomiting, diarrhea, constipation, and early fullness

There is also some evidence that a local GLP-1 system may exist within the pancreas
