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et la chane latrale de Lys 26 est prpare par synthse fragmentaire, et un fragment entirement protg de Fmoc-PEG-PEG--Glu-acide octadcanedioque utilis dans la synthse fragmentaire de la chane latrale de Lys 26 est prpar par le couplage successif d'une rsine de chlorure du Fmoc-PEG-OH, du Fmoc-PEG-OH, du Fmoc-Glu(OH)-OtBu et un ester mono-tert-buytlique d'acide octadcanedioque, clivage et recristallisation pour obtenir un PEG-PEG--Glu-ester mono-tert-butylique d'acide acide octadcanedioque

In the latter study, the corresponding increase was 5bpm with dulaglutide