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But researchers are now increasingly examining how the drugs may affect the brain, including areas tied to reward, motivation, addiction and emotional processing

Further research is needed to elucidate the precise mechanisms by which GLP-1R activation influences these complex neural circuits

Many patients posting on GLP-1 non-responder Reddit forums report diminishing motivation after months without results

These injections are usually prescribed to adults living with obesity, who have a body mass index (BMI) over 30, or over 27 if they have other weight-related health issues such as high blood pressure or prediabetes

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Gutierrez A.D., Gao Z., Hamidi V., Zhu L., Saint Andre K.B., Riggs K., Ruscheinsky M., Wang H., Yu Y., Miller C., III, et al

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