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It was put down to having an infection

Increased lysyl oxidase (LOX) expression in obesity-related adipose tissue contributes to the aggressiveness and metastasis of thyroid cancer, particularly when BRAF mutations are present [124]

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If using oral hormonal contraceptives, switch to a nonoral contraceptive method or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation with this drug