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The theoretical rationale for combination therapy rests on targeting multiple neurochemical systems: GLP-1 controls homeostatic appetite, while naltrexone modulates reward-based eating behavior

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[67] CHIP, Medicaid, and Medicare Coverage [edit] In April 2025, the Trump Administration declined to finalize a Biden Administration proposal that would have required Medicare, Medicaid, and the Children's Health Insurance Program (CHIP) to broadly cover GLP-1 drugs for weight loss

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GLP-1 drugs are best compared with the efficacy of bariatric surgery