glp-1 agonists and sglt2 inhibitors SGLT-2 Agonists: First-Line Therapy for Diabetes With Established Cardiovascular Disease SGLT2 Inhibitors and GLP-1 Receptor
Description
Berberine, an alkaloid compound derived from plants like barberry and goldenseal, has demonstrated modest metabolic effects in research studies

doi: 10.1111/j.1745-7270.2008.00438.x

A media frenzy followed

Direct effects of GLP-1 receptor agonism on the heart is likely not a major contributor

That being said only 4.1 % of patients stopped the 4mg dose which is less than the placebo arm

Traditionally, glucagon was viewed as an antagonist to insulin, raising blood sugar
