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Instead, the FDA cited 'deficiencies in the manufacturing and chemistry documentation (CMC).' This means the issues are related to the paperwork and processes around how the drug is made, rather than how well it works or its side effects in patients

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The concern with these medications is that the delayed gastric emptying leads to residual gastric contents, which may increase the risk of aspiration

Beyond Insulin: Using Ozempic and Other Off-Label Drugs for Type 1 Diabetes GLP-1 Receptor Agonists More and more clinicians are using GLP-1s off-label in people with type 1 diabetes, particularly in those who also have obesity or high insulin requirements, says Mihail Zilbermint, MD, an associate professor of medicine at Johns Hopkins University School of Medicine and the chief of the division of endocrinology, diabetes, and metabolism at Suburban Hospital in Maryland