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These agents activate the cAMP-PKA signaling cascade in pancreatic -cells 6 , resulting in glucose-dependent insulin secretion, suppression of pancreatic -cell glucagon release, and modulation of gastrointestinal motility through delayed gastric emptying 7

It improves blood sugar control and decreases appetite to reduce body weight

GLP-1RAs reduce circulating inflammatory mediators, suppress NLRP3 inflammasome activity, and lower oxidized LDL, thereby limiting the initiation of vascular injury

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Difficulty falling asleep (sleep onset insomnia) Trouble falling asleep within 20-30 minutes of lying down is the most commonly reported sleep problem on tirzepatide

I think it helps me to feel like the best version of myself