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To help visualise the expected weight loss at different doses, let's look at this comparative table: These percentages represent average weight loss from baseline over a 68-72 week period, based on the SURMOUNT-1 trial for Mounjaro and the STEP-1 trial for Wegovy

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10.3389/fendo.2020.00178 [DOI] [PMC free article] [PubMed] [Google Scholar] 8.Ibrahim SS, Ibrahim RS, Arabi B, Brockmueller A, Shakibaei M, Busselberg D (2024) The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer

Although the majority of absorbed Trp is directed into the kynurenine pathway via indoleamine 2,3-dioxygenase (IDO) in extrahepatic organs, or tryptophan 2,3-dioxygenase in the liver, culminating in NAD + synthesis [19], around 3% of absorbed Trp is converted into serotonin [20]