select trial glp 1 Discover How GLP-1 Trials Are Not One-Size-Fit-All GLP-1 Agonists For Obesity In

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Most side effects typically surface within the primary two weeks of treatment, with injection site reactions occurring almost immediately after administration

Those common side effects are typically gastrointestinal

However, despite the progress in the development of GLP-1 analogues, the overall efficacy of GLP-1 analogues for weight loss is still limited by gastrointestinal side effects, in particular nausea at higher doses (45)

For many, this is selflimiting and temporary

Furthermore, NTS GLP-1expressing neurons themselves do not express GLP-1R or respond to GLP-1RA (5658)