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VDR is associated with the intestinal barrier function, immune responses, and colitis, and it is also vital for the activation of NFB and the expression of tight junction proteins in the intestinal flora ( 3 [1,25(OH) 2 D 3 ], an active form of vitamin D, can directly interact with the intestinal flora and resist the lipopolysaccharides or TNF- ( 2 D 3 in the serum, but VDR expression can be down-regulated by pathogenic species such as Salmonella typhimurium in the intestine (Wu et al., 2010)

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The Chinese pharmaceutical company Sciwind Biosciences developed ecnoglutide, and has filed for the drugs approval in China for treatment of type 2 diabetes and obesity

J Diabetes (2014) 6(3):2606.10.1111/1753-0407.12102 23 YamadaCYamadaYTsukiyamaKYamadaKUdagawaNTakahashiNet alThe murine glucagon-like peptide-1 receptor is essential for control of bone resorption