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Ewald, C

In addition, the subcutaneous administration of RES effectively aggravated the neuropathic pain reported herein by reducing the (D) rearing frequencies in the open field test (OFT RF) in the FM group by 99% [F (2,27) = 22.87, p = 0.0001, 2 = 0.821]

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The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction

It does not decide whether semaglutide is appropriate, predict results, or replace clinical guidance

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