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Address sleep apnea if present, as this condition becomes less severe with weight loss

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(This does not include cholecystectomy, or gallbladder removal.) Severe gastrointestinal disease, such as ulcerative colitis or gastroparesis

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The compound dosing chart for tirzepatide provides detailed unit counts across all vial sizes and concentrations

In the REDEFINE 1 phase 3 trial (NCT05567796), which enrolled adults with overweight or obesity (BMI 27 kg/m) and at least 1 weight-related comorbidity but without type 2 diabetes, participants receiving CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) achieved a mean body weight reduction of 22.7% from baseline after 68 weeks among adherent participants, compared with approximately 3% in the placebo group.5 These results establish CagriSema as one of the most potent antiobesity therapies investigated to date