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After a reviewing the evidence from non-clinical studies, clinical trials, and data from post-marketing surveillance, The European Medicines Agency (EMA) committee concluded that NAION is associated with use of semaglutide (the active ingredient in Ozempic and Wegovy)

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To note, with the G-agonists, GIP receptors in the brain may respond differently than those peripherally, with less GI side effects

J Clin Anesth

Frequent Digestive Issues on Semaglutide If a patient frequently experiences nausea, vomiting, or diarrhea from semaglutide, they may be at higher risk for potassium depletion