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Access to experimental medications with unique mechanisms (not just another benzo or SSRI) Typically includes close monitoring, free medication, and medical supervision Phase 2 proven: rapid effect and clean side-effect profiles still need confirmation You might skip months of trial-and-error, or you might find a next-gen treatment actually feels "cleaner." Interested in clinical trials

However, those with a history of pancreatitis, specific types of thyroid cancer, or allergies to GLP-1 receptor agonists should consult their healthcare provider to weigh potential risks and benefits

Practice points are consensus statements about a specific aspect of care and represent the expert judgment of the guideline work group, but may also be based on limited evidence (not graded for strength or quality of evidence)

Adipose lipid turnover and long-term changes in body weight

Patients already taking metformin can seamlessly add PlexusDx semaglutide to their regimen under their healthcare provider's supervision

Further, while essentially all SGLT2 inhibitors have been shown to produce very similar effects on HF, progression of CKD, reduction in HbA1c and weight loss, there are major differences between the effect of different GLP-1 receptor agonists on all of these parameters