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Over a longer period, such as 72 weeks, clinical studies show average weight reductions of 15% to 21% of total body weight, especially when paired with healthy eating and physical activity

Semaglutide might increase this risk by causing fluid loss

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NICE has said semaglutide should be prescribed to adults who have at least one weight-related comorbidity and a BMI of at least 35kg/m2, alongside a reduced-calorie diet and increased physical activity

Both medications boast tirzepatide, a dual GIP and GLP-1 receptor agonist, yet they serve distinct functions