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These functions of GLP-1R in the CM model is mediated by its downstream PI3K/Akt pathway (Fig

Klein RZ, Haddow JE, Faix JD, Brown RS, Hermos RJ, Pulkkinen A, et al

This mechanism enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways
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