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doi: 10.1038/s41574-018-0016-2 20 CampbellJEDruckerDJ

Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes

Lilly has noted supply pressures for its incretin products

What takes people a year to build can be undone within half a year of stopping. Its also possible that the effects of going on and off a GLP-1 are too hard for the body to move past, says Mir Ali, MD, the medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California

Lastly, a study evaluating the impact of IL-1 gene polymorphism, leading to increased IL-1 levels, was shown to correlate with an increased rate of kidney disease in T2DM, mainly diabetic nephropathy [8]

Diabetes (2002) 51(8):24205