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Some patients feel optimal at 1.0 mg and experience meaningful weight loss without advancing further, while others tolerate and benefit from reaching the 2.4 mg maintenance dose

That goes for appetite changes, weight loss, and diabetes management

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25 In the STEP 1 extension, the semaglutide arm maintained a small improvement from baseline in HbA1c, and also in other cardiometabolic risk factors (LDL, VLDL and HDL cholesterol, triglycerides and CRP) after 1 year offtreatment, despite partial weight regain

22,23 Other studies have shown no association of exercise with bone health

The coming of age of the mitochondria-ER contact: a matter of thickness