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Weight loss is a major secondary benefit

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While these medications effectively reduce hunger for most people, some continue experiencing sugar cravings despite treatment

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GLP-1RA Therapy as a Chronic Flux Perturbation System-Level Energy Flux Reorganization Under Weight Loss Therapy Most weight-loss interventionsincluding exercise [49], calorie restriction [50], cold exposure [51], and selected antidiabetic agents [10, 52]ultimately increase reliance on FAO, which supplies acetyl-CoA to sustain tricarboxylic acid (TCA) cycle activity and electron transport chain (ETC)coupled adenosine triphosphate (ATP) production

Mitochondrial endpoints (citrate synthase activity, -oxidation flux) are added when energy expenditure is central to the hypothesis