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Glucagon-like peptide-1 (GLP-1) is an incretin hormone that enhances insulin secretion and exhibits anti-inflammatory, antioxidant and anti-apoptotic properties [9]

Peak concentration (Tmax) : 1272 hours post-dose in healthy volunteers

Vomiting Becomes Likely When the stomach cannot process the volume, the body may expel its contents

The single largest limitation is that no published, adequately powered study has evaluated CagriSema against biopsy-defined MASH endpoints

however, multiple animal studies have shown reductions in fibrosis after treatment [42, 43], supporting that the changes in ADC observed in this study may reflect other changes in kidney microanatomy

Some studies also suggest benefits for non-alcoholic fatty liver disease and obstructive sleep apnea