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For the groups randomized to placebo, 1.2 mg of pemvidutide, 1.8 mg, and 2.4 mg,, week-24 absolute reduction in liver volume, which is linked to overall mortality, was 3.3%, 12.6%, 19.1%, and 18.0%

Semaglutide alone achieved 10-22% weight loss in STEP trials, while phentermine produces 5-8% loss before tolerance develops

PMID: 30684032 Zhang Y, et al

Lindhardt, A

In women, weight loss may affect oestrogen metabolism and could potentially unmask or coincide with perimenopausal symptoms, including hot flushes