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Thyroid cancer The prescribing information for GLP-1RA lists MTC as a contraindication, based on a preclinical rodent study demonstrating that GLP-1R activation elevates cAMP levels in rodent thyroid C-cells, stimulates calcitonin release, and promotes C-cell hyperplasia and MTC development (200)
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Medical records documenting semaglutide use, ophthalmologic examinations, optic nerve findings, and a formal NAION diagnosis may help support a legal claim
doi: 10.1213/ane.0000000000006888 21
