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When Ozempic (semaglutide) was approved by the FDA in 2017, doctors quickly realized that diabetic patients who took the drug also lost weight

Glucose decreases Na + ,K + -ATPase activity in pancreatic -cells

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A longer study (mean follow-up of 3 years), found a lower risk for a composite outcome of kidney replacement therapy, or kidney failure-related hospitalization or death in initiators of GLP-1 RAs compared with DPP4i [29]

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Regular monitoring of renal function is advisable in patients with pre-existing kidney disease, as gastrointestinal adverse effects may lead to dehydration and acute kidney injury