glp 1 and kidney disease GLP-1 agonists in the treatment of chronic in type 2 diabetes obesity Nephroprotective effects of GLP-1 receptor

Description

GLP-1 promotes islet neogenesis, lowers blood glucose levels, upregulates Pdx1 expression, and increases -cell mass in db/db mice (Stoffers et al., 2000)

Discussion The crystallized inactive GLP-1R structure is not compatible with the known binding mode of GLP-1 requiring a conformational change of the ECD and a rearrangement of the TMD to enable binding of GLP-1

Clin Experimental Allergy: J Br Soc Allergy Clin Immunol

Li J, Woodward M, Perkovic V et al (2020) Mediators of the effects of canagliflozin on heart failure in patients with type 2 diabetes

BP-Lowering Effect: The American Diabetes Association (ADA) recommends tight glycemic control and BP reduction to help prevent chronic kidney disease (CKD) in patients with diabetes