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Inhibiting TRPV1 has proven effective in mitigating pain in diverse neuropathic pain models, thereby garnering interest from numerous pharmaceutical companies 22,23

Tirzepatide's dual mechanism may cause slightly higher rates of gastrointestinal side effects, but it remains a safe option for most patients

Sex distribution was not analyzed in our study, which is a limitation given evidence that females may be more susceptible to nausea and vomiting induced by GLP-1RAs, potentially due to hormonal influences or differences in gastric emptying rates

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is an advisory board member for Gilead Sciences, Inc., Janssen, and Lexicon Pharmaceuticals