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Weight loss injections, particularly GLP-1 receptor agonists like semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro), have revolutionized obesity management, but questions about their cardiovascular safety remain a priority for patients and clinicians

Doctors were reluctant to prescribe them and so people began searching for loopholes to buy them

Studies involving amphetamines also suggest that GLP-1 receptor activation may reduce stimulant-related reward behaviors and hyperactivity, although no clinical trials for stimulant use disorder were identified in the review

For example, Capozzi et al

Correspondence: Link to online article: Conflicts of interest: JRFW has acted as a consultant, speaker or advisory board member for, or his institution has received research funding from, Dr Falk, Enyo, GEHealthcare, Intercept, Metacrine, Novartis, Pendopharm and Prometheus

Hepatobiliary Events Gallbladder-related adverse events have been observed in retatrutide trials, consistent with observations across GLP-1 agonist studies more broadly