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Mumphrey MB, Hao Z, Townsend RL, Patterson LM, Berthoud H-R

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Rats receiving vagotomy do not reduce food intake in response to peripherally injected GLP-1 indicating that vagal afferent nerves are needed to relay peripheral GLP-1 signals to higher brain regions to regulate feeding (Abbott et al., Phox2b-Cre Glp1r flox/flox ) (Sisley et al., Phox2b-Cre Glp1r flox/flox mice fed a HFD reduced food intake, body weight, and adiposity suggesting that the PNS is not required for liraglutide to mediate its effects on energy metabolism

It should be discontinued upon recognition of pregnancy and is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

Once you stop taking the drug, your digestive system returns to its normal pace

This is mainly due to the rapid growth in anti-obesity treatment adoption