glp 1 headaches from GLP-1 Injections GLP-1 Drug Cuts Migraine Days

PMID: 46 ZhangZZhangQTanYChenYZhouXLiuSet al

SURPASS-4 Compared tirzepatide with people on metformin, and/or sulfonylureas and/or SGLT-2s with Insulin Glargine in people with increased cardiovascular risk

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It is a dual agonist that stimulates both GLP-1 and GIP receptors

GIP is secreted by the enteroendocrine K-cells concentrated in the proximal intestines, including the duodenum and jejunum ( via both neural and endocrine mediated factors ( Incretins act on G-protein coupled receptors on the beta cells of the pancreas, leading to a cAMP mediated pathway that ultimately results in insulin secretion ( Figure 1 )