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For example, in the oral contraceptive (OC)-SELENA and hormone replacement therapy (HRT)-SELENA studies, 60% and 50% of patients receiving a placebo, respectively, experienced at least one mild or moderate flare during the 12 month follow-up periods [12, 17]

HEK293T cells (obtained from and certified by the Cell Bank at the Chinese Academy of Sciences and confirmed as negative for mycoplasma contamination) were cultured in DMEM supplemented with 10% (v/v) foetal bovine serum, 50 IU mL 1 penicillin and 50 g mL 1 streptomycin

This gradual rise and fall prevents the dramatic spikes and crashes seen with faster-acting compounds, contributing to better tolerability and sustained appetite suppression throughout the week

Regular blood pressure checks are important, particularly during the dose escalation phase of Wegovy (the first 16-20 weeks)

Effects accelerate when increasing to 4mg and 8mg
