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Semaglutide-treated hepatocytes also had increased expression of genes related to adipocytokine signalling, glucagon signalling, AMPK signalling, insulin signalling, and steroid hormone biosynthesis compared to hepatocytes of vehicle-treated animals ( Figure 6E )

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While emerging evidence suggests GLP-1 agonists may support mood alongside primary depression care, patients experiencing moderate to severe depression require evaluation by a mental health professional

doi: 10.1007/s00125-005-1913-1, PMID: [DOI] [PubMed] [Google Scholar] 109

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