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160,161 For example, HM15211, a triple agonist developed by Hanmi Pharmaceutical in South Korea that activates GLP-1R, GIPR and GCGR has entered early clinical trials for the treatment of obesity and non-alcoholic steatohepatitis (NASH)

2021;106:e4251e4259

This might include: Keeping a detailed symptom diary during semaglutide initiation Establishing thresholds for concerning symptoms (bloody stools, fever, severe pain) Planning for prompt fecal calprotectin testing or limited sigmoidoscopy if symptoms worsen Scheduling more frequent follow-up during the first 3-6 months of therapy Alternative treatment options should be explored
Tirzepatide should not be used if you have a family history of MTC or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

With strategic, integrated care, patients can get the benefits of using GLP-1 drugs without the debilitating side effects, and employers and health plans can manage the costs associated with GLP-1s without impacting the health of the people they serve

Glucose- and bile acid-stimulated secretion of gut hormones in the isolated perfused intestine is not impaired in diet-induced obese mice
